5 posts

COVID-19 Drugs: Inhibiting viral replication and transcription

Remdesivir is the first drug to be recommended for treatment of COVID-19. Determining the structure of its target - the viral replication machinery - is an important step in understanding how it blocks viral replication, and how other antivirals could be designed.…


Computational power in the fight against COVID-19

Computational structural biology is a powerful tool in protein design and engineering. Let’s take a look at how it is being used to design protein therapeutics and vaccines targeting SARS-CoV-2…


SARS-CoV-2: structures light the path to vaccines and treatment

Shape of the viral spike revealedTo gain entry into human cells, the SARS-CoV-2 virus uses a “spike” on its surface, that recognizes receptors on human cells.…

Data availability

SARS-CoV-2: getting the data out there, and getting more from it

The processed X-ray diffraction data used to produce the structures of SARS-Cov-2 proteins are freely available. This means that anyone can improve these models using open source software. Better structures mean more biological insights.…

Structural biology

Structural Biology of SARS-CoV-2

Like many scientific communities, structural biologists have responded extraordinarily quickly in the fight against the coronavirus (SARS-CoV-2, also referred to as 2019-nCoV) and the resultant disease COVID-19, by determining the structure of many of the viral proteins.…