Structural biology

6 posts
Modelling

AlphaFold – changing the landscape of protein structure prediction

Structural biologists have an insatiable desire to discover the structure of proteins: for insight into how proteins work, and what that means for drug discovery.…

COVID-19

COVID-19 Drugs: Inhibiting viral replication and transcription

Remdesivir is the first drug to be recommended for treatment of COVID-19. Determining the structure of its target - the viral replication machinery - is an important step in understanding how it blocks viral replication, and how other antivirals could be designed.…

Vaccines

SARS-CoV-2: structures light the path to vaccines and treatment

To gain entry into human cells, the SARS-CoV-2 virus uses a “spike” on its surface, that recognizes receptors on human cells. One approach to making a vaccine is to immunise healthy patients with DNA or mRNA that codes for the spike protein.…

Data availability

SARS-CoV-2: getting the data out there, and getting more from it

The processed X-ray diffraction data used to produce the structures of SARS-Cov-2 proteins are freely available. This means that anyone can improve these models using open source software. Better structures mean more biological insights.…

Structural biology

Structural Biology of SARS-CoV-2

Like many scientific communities, structural biologists have responded extraordinarily quickly in the fight against the coronavirus (SARS-CoV-2, also referred to as 2019-nCoV) and the resultant disease COVID-19, by determining the structure of many of the viral proteins.…

Protein engineering and structural biology

It's a small world

Welcome to the PTNG blog. Here I will try to provide a commentary of some of the current news and events in science, medicine and biotech, in the context of structural biology and protein engineering.…